I ran two miles tonight on hilly roads. No knee pain at all. I felt great, accept for the fact that I was huffing and puffing going up hill, and felt totally out of shape, but that's OK, my legs didn't hurt! I still have a slight bit of limited mobility in my left ankle from the sprain, but it's nothing that really effects my running. I started off the first half mile pretty slow then picked up the speed as I went, averaging out to 7:50 pace.